Serum Metabolic Biomarkers of Liver Failure after Liver Resection
نویسندگان
چکیده
Introduction: Even the combination of PT and total bilirubin, known for being most reliable predictive conventional markers shows low sensitivity. Therefore we need to find more relevant biomarkers liver failure after resection focused on metabolites. Method: A 20 pigs were divided into 3 groups sham operation (n=6), 70% hepatectomy group (n=7), 90% (n=7). Blood sampling was performed preoperatively at 1, 6, 14, 30, 38, 48 hours systematically profiled 129 primary metabolites based gas-chromatography time-of-flight mass spectrometry. Results: Orthogonal projection latent structures-discriminant analysis revealed that central carbon metabolism significant factor in liver-resection contrast groups. Subsequent binary logistic regression used develop a model risk mortality following hepatectomy. The recommended variables malic acid, methionine, tryptophan, glucose, γ-aminobutyric acid. AUC linear 5 1.000 (95% confidence interval: 0.940-1.000, sensitivity: 100.0, specificity: 94.87) Conclusions: Systematic prioritization OPLS-DA proposed robust biomarker panels can accurately predict associated with
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ژورنال
عنوان ژورنال: Hpb
سال: 2021
ISSN: ['1365-182X', '1477-2574']
DOI: https://doi.org/10.1016/j.hpb.2020.11.493